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      "type": "VariantPathogenicityInterpretationGuideline",
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    },
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      "id": "MONDO:0700268",
      "label": "BRCA1-related cancer predisposition",
      "type": "GeneticCondition"
    },
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              "@id": "SEPIO:0000224",
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        ],
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        "id": "CG-PCER-VARINT:CA003681/MONDO:0700268/092/0/1738",
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        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
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                          "date": "2026/4/15",
                          "description": "Date on which this evidence was provided"
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                          "id": "SEPIO:0000516",
                          "label": "curator role",
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                      }
                    ],
                    "id": "CA003681/MONDO:0700268/092/ci/CA003681/MONDO:0700268/092.002",
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              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
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        },
        "id": "CG-PCER-VARINT:CA003681/MONDO:0700268/092/0/1588",
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                  "description": "Date on which this evidence was provided"
                },
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                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
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                "type": "Contribution"
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                "evidenceItem": [
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                        },
                        "comments": "This BRCA1 missense variant is within a key functional domain and the computational predictor BayesDel (noAF) gives a score of 0.533, above the recommended threshold of 0.28 for prediction of impact on BRCA1 function via protein change. SpliceAI predictor score of 0.00 suggests that the variant has no impact on splicing (score threshold <0.10) (PP3 met).",
                        "contributionDate": {
                          "date": "2026/4/15",
                          "description": "Date on which this evidence was provided"
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                          "label": "curator role",
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                        "type": "Contribution"
                      }
                    ],
                    "id": "CA003681/MONDO:0700268/092/ci/CA003681/MONDO:0700268/092.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA003681/MONDO:0700268/092/0/1747/1749",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA003681/MONDO:0700268/092/1/1748",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Met"
            },
            "type": "CriterionAssessment"
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        ],
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          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA003681/MONDO:0700268/092/0/1747",
        "type": "EvidenceLine"
      },
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        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA003681/MONDO:0700268/092/el/0/1636",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA003681/MONDO:0700268/092/ei/1/1637",
            "contribution": [
              {
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                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/4/15",
                  "description": "Date on which this evidence was provided"
                },
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                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
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                "type": "Contribution"
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                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA003681/MONDO:0700268/092/el/0/1636/1638",
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                ],
                "id": "CG-PCER-VARINT:CA003681/MONDO:0700268/092/0/1636/1638",
                "type": "EvidenceLine"
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            ],
            "id": "CG-PCER-VARINT:CA003681/MONDO:0700268/092/1/1637",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA003681/MONDO:0700268/092/0/1636",
        "type": "EvidenceLine"
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    ],
    "id": "CG-PCER-VARINT:CA003681/MONDO:0700268/092",
    "metadata": {
      "created": "2026-04-15T05:37:56.739Z",
      "note": "DISCLAIMER: While the data/content in this document is approved by ClinGen expert panel(s), the SEPIO schema presented here is an initial prototype and has not been reviewed nor finalized by the ClinGen Data Exchange Modeling Team. We expect it to differ significantly from the final schema.",
      "producedAtUTC": "Wed, 15 Apr 2026 05:37:56 -0000",
      "schemaLabel": "Evidence Repository.Beta-1 (Unofficial)",
      "version": "2.1.0"
    },
    "statementOutcome": {
      "@id": "https://loinc.org/LA6668-3",
      "id": "LN:LA6668-3",
      "label": "Pathogenic"
    },
    "type": "VariantPathogenicityInterpretation",
    "uuid": "03c35580-6129-4df7-b7b4-8055d39efda1",
    "variant": {
      "@id": "https://reg.genome.network/allele/CA003681",
      "id": "CAR:CA003681",
      "relatedContextualAllele": [
        {
          "alleleName": [
            {
              "name": "NM_007294.4:c.5509T>G"
            }
          ],
          "preferred": true
        }
      ],
      "relatedIdentifier": [
        {
          "label": "NM_007294.4(BRCA1):c.5509T>G (p.Trp1837Gly)"
        }
      ],
      "type": "CAR"
    }
  },
  "metadata": {
    "rendered": {
      "by": "https://erepo.genome.network/evrepo/api/summary/srvc",
      "when": "2026-11-03T18:27:02.545Z"
    }
  },
  "status": {
    "code": 200,
    "name": "OK"
  }
}