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                          "type": "Agent"
                        },
                        "comments": "Novel missense change at amino acid position where different missense change has been deemed likely pathogenic. PTEN c.477G>T (p.Arg159Ser) classified as likely pathogenic by Clingen PTEN Variant Curation Panel. BLOSUM 62 score for Arg/Lys change greater than Arg/Ser change, due to this weight for PM5_M is not applied.",
                        "contributionDate": {
                          "date": "2025/10/27",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA377482801/MONDO:0017623/003/ci/CA377482801/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA377482801/MONDO:0017623/003/0/1780/1782",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA377482801/MONDO:0017623/003/1/1781",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA377482801/MONDO:0017623/003/0/1780",
        "type": "EvidenceLine"
      }
    ],
    "id": "CG-PCER-VARINT:CA377482801/MONDO:0017623/003",
    "metadata": {
      "created": "2025-10-27T16:26:22.353Z",
      "note": "DISCLAIMER: While the data/content in this document is approved by ClinGen expert panel(s), the SEPIO schema presented here is an initial prototype and has not been reviewed nor finalized by the ClinGen Data Exchange Modeling Team. We expect it to differ significantly from the final schema.",
      "producedAtUTC": "Mon, 27 Oct 2025 16:26:21 -0000",
      "schemaLabel": "Evidence Repository.Beta-1 (Unofficial)",
      "version": "1.0.0"
    },
    "statementOutcome": {
      "@id": "https://loinc.org/LA6668-3",
      "id": "LN:LA6668-3",
      "label": "Pathogenic"
    },
    "type": "VariantPathogenicityInterpretation",
    "uuid": "4cd22c47-1e9d-469a-8faf-fd5b3fcf863e",
    "variant": {
      "@id": "https://reg.genome.network/allele/CA377482801",
      "id": "CAR:CA377482801",
      "relatedContextualAllele": [
        {
          "alleleName": [
            {
              "name": "NM_000314.8:c.476G>A"
            }
          ],
          "preferred": true
        }
      ],
      "relatedIdentifier": [
        {
          "label": "NM_000314.8(PTEN):c.476G>A (p.Arg159Lys)"
        }
      ],
      "type": "CAR"
    }
  },
  "metadata": {
    "rendered": {
      "by": "https://erepo.genome.network/evrepo/api/summary/srvc",
      "when": "2026-10-14T02:07:58.936Z"
    }
  },
  "status": {
    "code": 200,
    "name": "OK"
  }
}