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      "type": "VariantPathogenicityInterpretationGuideline",
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      "id": "MONDO:0018544",
      "label": "adrenoleukodystrophy",
      "type": "GeneticCondition"
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                          "date": "2026/4/15",
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                    ],
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            ],
            "id": "CG-PCER-VARINT:CA337233489/MONDO:0018544/105/1/1685",
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              "@id": "SEPIO:0000224",
              "label": "Not Met"
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                },
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                  "label": "curator role",
                  "type": "ContributoryRole"
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                "type": "Contribution"
              }
            ],
            "evidenceLine": [
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                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA337233489/MONDO:0018544/105/el/0/1645/1647",
                "evidenceItem": [
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                    "@id": "CG-PCER:curatorInference/CA337233489/MONDO:0018544/105/ci/EV000001976",
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                        "contributionDate": {
                          "date": "2026/4/15",
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                        "type": "Contribution"
                      }
                    ],
                    "id": "CA337233489/MONDO:0018544/105/ci/EV000001976",
                    "traceableAuthorStatement": "https://www.ncbi.nlm.nih.gov/pubmed/23300730",
                    "type": "CuratorInference"
                  }
                ],
                "id": "CG-PCER-VARINT:CA337233489/MONDO:0018544/105/0/1645/1647",
                "type": "EvidenceLine"
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            ],
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            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Met"
            },
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          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA337233489/MONDO:0018544/105/0/1645",
        "type": "EvidenceLine"
      },
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        "evidenceItem": [
          {
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            "contribution": [
              {
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                  "id": "CG-PCER-AGENT:CG_50049_EP177618055787822",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/4/15",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA337233489/MONDO:0018544/105/el/0/1804/1806",
                "evidenceItem": [
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                        "comments": "The filtering allele frequency (the lower threshold of the 95% CI of 8/1038015) of the c.55G>T (p.Ala19Ser) variant in ABCD1 is 0.00007991 for African/African American exomes by gnomAD\nv4.1, which is higher than the ClinGen Peroxisomal Disorders VCEP threshold (>=0.000017) for BS1, and therefore meets this criterion (BS1). 4 hemizygotes are noted in gnomAD v4.1 for this variant. ",
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                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
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                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA337233489/MONDO:0018544/105/ci/CA337233489/MONDO:0018544/105.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA337233489/MONDO:0018544/105/0/1804/1806",
                "type": "EvidenceLine"
              }
            ],
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            "statementOutcome": {
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              "label": "Met"
            },
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          }
        ],
        "evidenceStrength": {
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        },
        "id": "CG-PCER-VARINT:CA337233489/MONDO:0018544/105/0/1804",
        "type": "EvidenceLine"
      }
    ],
    "id": "CG-PCER-VARINT:CA337233489/MONDO:0018544/105",
    "metadata": {
      "created": "2026-04-15T15:19:06.928Z",
      "note": "DISCLAIMER: While the data/content in this document is approved by ClinGen expert panel(s), the SEPIO schema presented here is an initial prototype and has not been reviewed nor finalized by the ClinGen Data Exchange Modeling Team. We expect it to differ significantly from the final schema.",
      "producedAtUTC": "Wed, 15 Apr 2026 15:19:06 -0000",
      "schemaLabel": "Evidence Repository.Beta-1 (Unofficial)",
      "version": "1.0.0"
    },
    "statementOutcome": {
      "@id": "https://loinc.org/LA26334-5",
      "id": "LN:LA26334-5",
      "label": "Likely Benign"
    },
    "type": "VariantPathogenicityInterpretation",
    "uuid": "9f04e4c4-f0d8-4e61-a41e-e9ee7032453b",
    "variant": {
      "@id": "https://reg.genome.network/allele/CA337233489",
      "id": "CAR:CA337233489",
      "relatedContextualAllele": [
        {
          "alleleName": [
            {
              "name": "NM_000033.4:c.55G>T"
            }
          ],
          "preferred": true
        }
      ],
      "relatedIdentifier": [
        {
          "label": "NM_000033.4(ABCD1):c.55G>T (p.Ala19Ser)"
        }
      ],
      "type": "CAR"
    }
  },
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    "rendered": {
      "by": "https://erepo.genome.network/evrepo/api/summary/srvc",
      "when": "2026-10-13T23:14:58.636Z"
    }
  },
  "status": {
    "code": 200,
    "name": "OK"
  }
}