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                            "date": "2024/6/12",
                            "description": "Date on which this evidence was provided"
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                            "id": "SEPIO:0000516",
                            "label": "curator role",
                            "type": "ContributoryRole"
                          },
                          "type": "Contribution"
                        }
                      ],
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                "label": "Not Met"
              },
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            }
          ],
          "evidenceStrength": {
            "@id": "https://obofoundry.org/sepio"
          },
          "id": "CG-PCER-VARINT:CA022758/MONDO:0700269/097/0/1777",
          "type": "EvidenceLine"
        }
      ],
      "id": "CG-PCER-VARINT:CA022758/MONDO:0700269/097",
      "metadata": {
        "created": "2024-09-28T04:44:29.037Z",
        "note": "DISCLAIMER: While the data/content in this document is approved by ClinGen expert panel(s), the SEPIO schema presented here is an initial prototype and has not been reviewed nor finalized by the ClinGen Data Exchange Modeling Team. We expect it to differ significantly from the final schema.",
        "producedAtUTC": "Sat, 28 Sep 2024 04:44:28 -0000",
        "schemaLabel": "Evidence Repository.Beta-1 (Unofficial)",
        "version": "2.0.0"
      },
      "statementOutcome": {
        "@id": "https://loinc.org/LA26334-5",
        "id": "LN:LA26334-5",
        "label": "Likely Benign"
      },
      "type": "VariantPathogenicityInterpretation",
      "uuid": "db821c01-c24e-4cd0-a4ab-97da70f8fb35",
      "variant": {
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        "id": "CAR:CA022758",
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          {
            "alleleName": [
              {
                "name": "NM_000059.4:c.5632_5634del"
              }
            ],
            "preferred": true
          }
        ],
        "relatedIdentifier": [
          {
            "label": "NM_000059.4:c.5632_5634del"
          }
        ],
        "type": "CAR"
      }
    },
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        "type": "VariantPathogenicityInterpretationGuideline",
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      },
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        "id": "MONDO:0012933",
        "label": "breast-ovarian cancer, familial, susceptibility to, 2",
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                "label": "Not Met"
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              "id": "CG-PCER-VARINT:CA022758/MONDO:0012933/097/1/1721",
              "statementOutcome": {
                "@id": "SEPIO:0000224",
                "label": "Met"
              },
              "type": "CriterionAssessment"
            }
          ],
          "evidenceStrength": {
            "@id": "https://obofoundry.org/sepio"
          },
          "id": "CG-PCER-VARINT:CA022758/MONDO:0012933/097/0/1720",
          "type": "EvidenceLine"
        },
        {
          "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA022758/MONDO:0012933/097/el/0/1798",
          "evidenceItem": [
            {
              "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA022758/MONDO:0012933/097/ei/1/1799",
              "contribution": [
                {
                  "agent": {
                    "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50087_EP169680482377844",
                    "id": "CG-PCER-AGENT:CG_50087_EP169680482377844",
                    "type": "Agent"
                  },
                  "contributionDate": {
                    "date": "2023/10/10",
                    "description": "Date on which this evidence was provided"
                  },
                  "contributionRole": {
                    "@id": "https://obofoundry.org/sepio/0000156",
                    "id": "SEPIO:0000516",
                    "label": "curator role",
                    "type": "ContributoryRole"
                  },
                  "type": "Contribution"
                }
              ],
              "criterion": {
                "@id": "https://obofoundry.org/sepio/clingen/0011",
                "defaultStrength": {
                  "@id": "https://obofoundry.org/sepio/SEPIO:0000216",
                  "id": "SEPIO:0000216",
                  "label": "Pathogenic Moderate"
                },
                "id": "0011",
                "label": "PM2",
                "type": "Criterion"
              },
              "evidenceLine": [
                {
                  "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA022758/MONDO:0012933/097/el/0/1798/1800",
                  "evidenceItem": [
                    {
                      "@id": "CG-PCER:curatorInference/CA022758/MONDO:0012933/097/ci/CA022758/MONDO:0012933/097.002",
                      "contribution": [
                        {
                          "agent": {
                            "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50087_EP169680482377844",
                            "id": "CG-PCER-AGENT:CG_50087_EP169680482377844",
                            "type": "Agent"
                          },
                          "comments": "This variant is present in gnomAD v2.1 (exomes only, non-cancer subset) or gnomAD v3.1 (non-cancer subset) but is below the ENIGMA BRCA1/2 VCEP threshold >0.00002 for BS1_Supporting (PM2_Supporting, BS1, and BA1 are not met). ",
                          "contributionDate": {
                            "date": "2023/10/10",
                            "description": "Date on which this evidence was provided"
                          },
                          "contributionRole": {
                            "@id": "https://obofoundry.org/sepio/0000156",
                            "id": "SEPIO:0000516",
                            "label": "curator role",
                            "type": "ContributoryRole"
                          },
                          "type": "Contribution"
                        }
                      ],
                      "id": "CA022758/MONDO:0012933/097/ci/CA022758/MONDO:0012933/097.002",
                      "type": "InfFromBkgrndSciKnow"
                    }
                  ],
                  "id": "CG-PCER-VARINT:CA022758/MONDO:0012933/097/0/1798/1800",
                  "type": "EvidenceLine"
                }
              ],
              "id": "CG-PCER-VARINT:CA022758/MONDO:0012933/097/1/1799",
              "statementOutcome": {
                "@id": "SEPIO:0000224",
                "label": "Not Met"
              },
              "type": "CriterionAssessment"
            }
          ],
          "evidenceStrength": {
            "@id": "https://obofoundry.org/sepio"
          },
          "id": "CG-PCER-VARINT:CA022758/MONDO:0012933/097/0/1798",
          "type": "EvidenceLine"
        },
        {
          "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA022758/MONDO:0012933/097/el/0/1777",
          "evidenceItem": [
            {
              "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA022758/MONDO:0012933/097/ei/1/1778",
              "contribution": [
                {
                  "agent": {
                    "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50087_EP169680482377844",
                    "id": "CG-PCER-AGENT:CG_50087_EP169680482377844",
                    "type": "Agent"
                  },
                  "contributionDate": {
                    "date": "2023/10/10",
                    "description": "Date on which this evidence was provided"
                  },
                  "contributionRole": {
                    "@id": "https://obofoundry.org/sepio/0000156",
                    "id": "SEPIO:0000516",
                    "label": "curator role",
                    "type": "ContributoryRole"
                  },
                  "type": "Contribution"
                }
              ],
              "criterion": {
                "@id": "https://obofoundry.org/sepio/clingen/0087",
                "defaultStrength": {
                  "@id": "https://obofoundry.org/sepio/SEPIO:0000325",
                  "id": "SEPIO:0000325",
                  "label": "Benign Stand Alone"
                },
                "id": "0087",
                "label": "BA1",
                "type": "Criterion"
              },
              "evidenceLine": [
                {
                  "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA022758/MONDO:0012933/097/el/0/1777/1779",
                  "evidenceItem": [
                    {
                      "@id": "CG-PCER:curatorInference/CA022758/MONDO:0012933/097/ci/CA022758/MONDO:0012933/097.002",
                      "contribution": [
                        {
                          "agent": {
                            "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50087_EP169680482377844",
                            "id": "CG-PCER-AGENT:CG_50087_EP169680482377844",
                            "type": "Agent"
                          },
                          "comments": "This variant is present in gnomAD v2.1 (exomes only, non-cancer subset) or gnomAD v3.1 (non-cancer subset) but is below the ENIGMA BRCA1/2 VCEP threshold >0.00002 for BS1_Supporting (PM2_Supporting, BS1, and BA1 are not met). ",
                          "contributionDate": {
                            "date": "2023/10/10",
                            "description": "Date on which this evidence was provided"
                          },
                          "contributionRole": {
                            "@id": "https://obofoundry.org/sepio/0000156",
                            "id": "SEPIO:0000516",
                            "label": "curator role",
                            "type": "ContributoryRole"
                          },
                          "type": "Contribution"
                        }
                      ],
                      "id": "CA022758/MONDO:0012933/097/ci/CA022758/MONDO:0012933/097.002",
                      "type": "InfFromBkgrndSciKnow"
                    }
                  ],
                  "id": "CG-PCER-VARINT:CA022758/MONDO:0012933/097/0/1777/1779",
                  "type": "EvidenceLine"
                }
              ],
              "id": "CG-PCER-VARINT:CA022758/MONDO:0012933/097/1/1778",
              "statementOutcome": {
                "@id": "SEPIO:0000224",
                "label": "Not Met"
              },
              "type": "CriterionAssessment"
            }
          ],
          "evidenceStrength": {
            "@id": "https://obofoundry.org/sepio"
          },
          "id": "CG-PCER-VARINT:CA022758/MONDO:0012933/097/0/1777",
          "type": "EvidenceLine"
        }
      ],
      "id": "CG-PCER-VARINT:CA022758/MONDO:0012933/097",
      "metadata": {
        "created": "2024-09-28T03:01:28.438Z",
        "note": "DISCLAIMER: While the data/content in this document is approved by ClinGen expert panel(s), the SEPIO schema presented here is an initial prototype and has not been reviewed nor finalized by the ClinGen Data Exchange Modeling Team. We expect it to differ significantly from the final schema.",
        "producedAtUTC": "Sat, 28 Sep 2024 03:01:28 -0000",
        "schemaLabel": "Evidence Repository.Beta-1 (Unofficial)",
        "version": "1.0.0"
      },
      "statementOutcome": {
        "@id": "https://loinc.org/LA26334-5",
        "id": "LN:LA26334-5",
        "label": "Likely Benign"
      },
      "type": "VariantPathogenicityInterpretation",
      "uuid": "db821c01-c24e-4cd0-a4ab-97da70f8fb35",
      "variant": {
        "@id": "https://reg.genome.network/allele/CA022758",
        "id": "CAR:CA022758",
        "relatedContextualAllele": [
          {
            "alleleName": [
              {
                "name": "NM_000059.4:c.5632_5634del"
              }
            ],
            "preferred": true
          }
        ],
        "type": "CAR"
      }
    }
  ],
  "metadata": {
    "rendered": {
      "by": "https://erepo.genome.network/evrepo/api/summary/srvc",
      "when": "2026-10-13T20:10:43.721Z"
    }
  },
  "status": {
    "code": 200,
    "name": "OK"
  }
}