{
  "data": {
    "@context": "https://erepo.genome.network/evrepo/api/context",
    "@id": "https://erepo.genome.network/evrepo/api/summary/classification/e75a40b0-8e18-418e-b6c7-079646958d18/doc/sepio/version/1.1.0",
    "assertionMethod": {
      "@id": "https://cspec.genome.network/cspec/SequenceVariantInterpretation/id/135637575",
      "label": "ClinGen PTEN Expert Panel Specifications to the ACMG/AMP Variant Interpretation Guidelines for PTEN Version 3.1.0",
      "type": "VariantPathogenicityInterpretationGuideline",
      "version": "3.1.0"
    },
    "condition": {
      "@id": "https://api.monarchinitiative.org/api/bioentity/phenotype/MONDO:0017623",
      "id": "MONDO:0017623",
      "label": "PTEN hamartoma tumor syndrome",
      "type": "GeneticCondition"
    },
    "evidenceLine": [
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1804",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1805",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1804/1806",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "comments": "gnomAD v2.1.1: 19/125384 (.0115%) European/non-Finnish pop (.00011515). Popmax Filtering AF is .0001051 which meets BS1 criteria [gnomAD Filtering allele frequency from 0.000043 (0.0043%) up to 0.00056 (0.056%)].\n",
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1804/1806",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1805",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1804",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1768",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1769",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1768/1770",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1768/1770",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1769",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1768",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1579",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1580",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1579/1581",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "comments": "Some cases suggestive, but overlapping phenotypes with PHTS",
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1579/1581",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1580",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1579",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1654",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1655",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1654/1656",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1654/1656",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1655",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1654",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1615",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1616",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1615/1617",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1615/1617",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1616",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1615",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1717",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1718",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1717/1719",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1717/1719",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1718",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1717",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1780",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1781",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1780/1782",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1780/1782",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1781",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1780",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1591",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1592",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1591/1593",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1591/1593",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1592",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1591",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1672",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1673",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1672/1674",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1672/1674",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1673",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1672",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1798",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1799",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1798/1800",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "comments": "0.015% (19/122,896) European (Non-Finnish) alleles in gnomAD; 3/1886 alleles in GME variome.",
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1798/1800",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1799",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1798",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1594",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1595",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1594/1596",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1594/1596",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1595",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1594",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1678",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1679",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1678/1680",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1678/1680",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1679",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1678",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1837",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1838",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1837/1839",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "comments": "PTEN is defined by the PTEN Expert Panel as a gene that has a low rate of benign missense variation and where missense variants are a common mechanism of disease.",
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1837/1839",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1838",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1837",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1747",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1748",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1747/1749",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1747/1749",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1748",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1747",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1633",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1634",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1633/1635",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/EV000000274",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "comments": "Identified in a pt with BrCA dx 57 who had a FDR with BrCA.",
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/EV000000274",
                    "traceableAuthorStatement": "https://www.ncbi.nlm.nih.gov/pubmed/26898890",
                    "type": "CuratorInference"
                  },
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/EV000000275",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "comments": "Identified in a pt undergoing clinical testing; no phenotype info provided.",
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/EV000000275",
                    "traceableAuthorStatement": "https://www.ncbi.nlm.nih.gov/pubmed/21659347",
                    "type": "CuratorInference"
                  },
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/EV000000276",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "comments": "Eng lab paper, same pts in other lab publications.  Identified in two sisters. The first being a 49 year old woman with normal head circumference and a history of breast cancer, fibrocystic breast disease and uterine fibroids. Reported to NOT meet ICC criteria. The second being a 56 year old female (head circumference unknown) with a history of fibrocystic breast disease and a genitourinary tumor. This patient also did NOT meet ICC criteria.",
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/EV000000276",
                    "traceableAuthorStatement": "https://www.ncbi.nlm.nih.gov/pubmed/21343951",
                    "type": "CuratorInference"
                  },
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/EV000000243",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "comments": "Seen in a pt with a Lynch-related cancer and/or polyps who also harbored an MSH2 PATH, but no phenotype provided.",
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/EV000000243",
                    "traceableAuthorStatement": "https://www.ncbi.nlm.nih.gov/pubmed/25980754",
                    "type": "CuratorInference"
                  },
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/EV000000261",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "comments": "Germline finding in a pt with neuroblastoma",
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/EV000000261",
                    "traceableAuthorStatement": "https://www.ncbi.nlm.nih.gov/pubmed/26580448",
                    "type": "CuratorInference"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1633/1635",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1634",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1633",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1702",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1703",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1702/1704",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1702/1704",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1703",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1702",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1684",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1685",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1684/1686",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "comments": "REVEL score < 0.5 (score=0.497)",
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1684/1686",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1685",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1684",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1789",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1790",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1789/1791",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1789/1791",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1790",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1789",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1726",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1727",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1726/1728",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1726/1728",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1727",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1726",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1597",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1598",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1597/1599",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1597/1599",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1598",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1597",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1645",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1646",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1645/1647",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/EV000000271",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "comments": "WT-like abundance on high-throughput VAMP-seq assay, indicating stable protein",
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/EV000000271",
                    "traceableAuthorStatement": "https://www.ncbi.nlm.nih.gov/pubmed/29785012",
                    "type": "CuratorInference"
                  },
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/EV000000266",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "comments": "Score of 0.09 (WT-like range) on high throughput phosphatase assay",
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/EV000000266",
                    "traceableAuthorStatement": "https://www.ncbi.nlm.nih.gov/pubmed/29706350",
                    "type": "CuratorInference"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1645/1647",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1646",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1645",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1777",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1778",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1777/1779",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "comments": "0.015% (19/122,896) European (Non-Finnish) alleles in gnomAD; 3/1886 alleles in GME variome.",
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1777/1779",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1778",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1777",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1765",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1766",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1765/1767",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1765/1767",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1766",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1765",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1663",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1664",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1663/1665",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1663/1665",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1664",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1663",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1828",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1829",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1828/1830",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1828/1830",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1829",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1828",
        "type": "EvidenceLine"
      },
      {
        "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1735",
        "evidenceItem": [
          {
            "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/ei/1/1736",
            "contribution": [
              {
                "agent": {
                  "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                  "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                  "type": "Agent"
                },
                "contributionDate": {
                  "date": "2026/6/8",
                  "description": "Date on which this evidence was provided"
                },
                "contributionRole": {
                  "@id": "https://obofoundry.org/sepio/0000156",
                  "id": "SEPIO:0000516",
                  "label": "curator role",
                  "type": "ContributoryRole"
                },
                "type": "Contribution"
              }
            ],
            "evidenceLine": [
              {
                "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA000275/MONDO:0017623/003/el/0/1735/1737",
                "evidenceItem": [
                  {
                    "@id": "CG-PCER:curatorInference/CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "contribution": [
                      {
                        "agent": {
                          "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50012_EP15519033251287",
                          "id": "CG-PCER-AGENT:CG_50012_EP15519033251287",
                          "type": "Agent"
                        },
                        "contributionDate": {
                          "date": "2026/6/8",
                          "description": "Date on which this evidence was provided"
                        },
                        "contributionRole": {
                          "@id": "https://obofoundry.org/sepio/0000156",
                          "id": "SEPIO:0000516",
                          "label": "curator role",
                          "type": "ContributoryRole"
                        },
                        "type": "Contribution"
                      }
                    ],
                    "id": "CA000275/MONDO:0017623/003/ci/CA000275/MONDO:0017623/003.002",
                    "type": "InfFromBkgrndSciKnow"
                  }
                ],
                "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1735/1737",
                "type": "EvidenceLine"
              }
            ],
            "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/1/1736",
            "statementOutcome": {
              "@id": "SEPIO:0000224",
              "label": "Not Met"
            },
            "type": "CriterionAssessment"
          }
        ],
        "evidenceStrength": {
          "@id": "https://obofoundry.org/sepio"
        },
        "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003/0/1735",
        "type": "EvidenceLine"
      }
    ],
    "id": "CG-PCER-VARINT:CA000275/MONDO:0017623/003",
    "metadata": {
      "created": "2026-06-08T19:48:03.218Z",
      "note": "DISCLAIMER: While the data/content in this document is approved by ClinGen expert panel(s), the SEPIO schema presented here is an initial prototype and has not been reviewed nor finalized by the ClinGen Data Exchange Modeling Team. We expect it to differ significantly from the final schema.",
      "producedAtUTC": "Mon, 08 Jun 2026 19:48:03 -0000",
      "schemaLabel": "Evidence Repository.Beta-1 (Unofficial)",
      "version": "1.1.0"
    },
    "statementOutcome": {
      "@id": "https://loinc.org/LA26334-5",
      "id": "LN:LA26334-5",
      "label": "Likely Benign"
    },
    "type": "VariantPathogenicityInterpretation",
    "uuid": "e75a40b0-8e18-418e-b6c7-079646958d18",
    "variant": {
      "@id": "https://reg.genome.network/allele/CA000275",
      "id": "CAR:CA000275",
      "relatedContextualAllele": [
        {
          "alleleName": [
            {
              "name": "NM_000314.8:c.1061C>A"
            }
          ],
          "preferred": true
        }
      ],
      "relatedIdentifier": [
        {
          "label": "NM_000314.8(PTEN):c.1061C>A (p.Pro354Gln)"
        }
      ],
      "type": "CAR"
    }
  },
  "metadata": {
    "rendered": {
      "by": "https://erepo.genome.network/evrepo/api/summary/srvc",
      "when": "2026-06-27T09:18:05.928Z"
    }
  },
  "status": {
    "code": 200,
    "name": "OK"
  }
}