{ "data": { "@context": "https://erepo.genome.network/evrepo/api/context", "@id": "https://cgerepoapi/evrepo/api/summary/classification/eab22ed7-b1c5-444f-ba9f-0de25bfa14bd/doc/sepio/version/1.0.0", "assertionMethod": { "@id": "https://cspec.genome.network/cspec/SequenceVariantInterpretation/id/1562840326", "label": "ClinGen Severe Combined Immunodeficiency Disease Expert Panel Specifications to the ACMG/AMP Variant Interpretation Guidelines for FOXN1 Version 1.0.0", "type": "VariantPathogenicityInterpretationGuideline", "version": "1.0.0" }, "condition": { "@id": "https://api.monarchinitiative.org/api/bioentity/phenotype/MONDO:0011132", "id": "MONDO:0011132", "label": "T-cell immunodeficiency, congenital alopecia, and nail dystrophy", "type": "GeneticCondition" }, "evidenceLine": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1678", "evidenceItem": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/ei/1/1679", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "criterion": { "@id": "https://obofoundry.org/sepio/clingen/0060", "defaultStrength": { "@id": "https://obofoundry.org/sepio/SEPIO:0000329", "id": "SEPIO:0000329", "label": "Pathogenic Supporting" }, "id": "0060", "label": "PP1", "type": "Criterion" }, "evidenceLine": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1678/1680", "evidenceItem": [ { "@id": "CG-PCER:curatorInference/CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "comments": "Siblings P1 and P2 (PMID: 30903456) are both affected with T-B+NK+ SCID and homozygous for this variant, the parents are both heterozygous and do not have any immunodeficiency but have decreased T cell counts and reduced TREC levels compared to age-matched controls.", "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "id": "CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "type": "InfFromBkgrndSciKnow" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1678/1680", "type": "EvidenceLine" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/1/1679", "statementOutcome": { "@id": "SEPIO:0000224", "label": "Met" }, "type": "CriterionAssessment" } ], "evidenceStrength": { "@id": "https://obofoundry.org/sepio" }, "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1678", "type": "EvidenceLine" }, { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1747", "evidenceItem": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/ei/1/1748", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "criterion": { "@id": "https://obofoundry.org/sepio/clingen/0062", "defaultStrength": { "@id": "https://obofoundry.org/sepio/SEPIO:0000329", "id": "SEPIO:0000329", "label": "Pathogenic Supporting" }, "id": "0062", "label": "PP3", "type": "Criterion" }, "evidenceLine": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1747/1749", "evidenceItem": [ { "@id": "CG-PCER:curatorInference/CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "comments": "The variant has a REVEL score of 0.731 which is above the SCID VCEP specified threshold of ≥0.644 to support a deleterious effect of the variant (PP3).", "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "id": "CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "type": "InfFromBkgrndSciKnow" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1747/1749", "type": "EvidenceLine" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/1/1748", "statementOutcome": { "@id": "SEPIO:0000224", "label": "Met" }, "type": "CriterionAssessment" } ], "evidenceStrength": { "@id": "https://obofoundry.org/sepio" }, "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1747", "type": "EvidenceLine" }, { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1633", "evidenceItem": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/ei/1/1634", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "criterion": { "@id": "https://obofoundry.org/sepio/clingen/0063", "defaultStrength": { "@id": "https://obofoundry.org/sepio/SEPIO:0000329", "id": "SEPIO:0000329", "label": "Pathogenic Supporting" }, "id": "0063", "label": "PP4", "type": "Criterion" }, "evidenceLine": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1633/1635", "evidenceItem": [ { "@id": "CG-PCER:curatorInference/CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "comments": "Patient P2 (PMID: 30903456) homozygous for this variant, was diagnosed with T-B+NK+ SCID with absent CD3+ cells (0.5pt). There were also absent TRECs and a poor proliferative response to PHA, athymia, alopecia totalis (0.25pt), and nail dystrophy (0.25pt). The patient was sequenced using a NGS panel of 18 common SCID-related genes and Sanger sequencing for FOXN1 (0.5pt). Total 1.5pt (PP4)", "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "id": "CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "type": "InfFromBkgrndSciKnow" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1633/1635", "type": "EvidenceLine" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/1/1634", "statementOutcome": { "@id": "SEPIO:0000224", "label": "Met" }, "type": "CriterionAssessment" } ], "evidenceStrength": { "@id": "https://obofoundry.org/sepio" }, "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1633", "type": "EvidenceLine" }, { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1636", "evidenceItem": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/ei/1/1637", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "criterion": { "@id": "https://obofoundry.org/sepio/clingen/0030", "defaultStrength": { "@id": "https://obofoundry.org/sepio/SEPIO:0000329", "id": "SEPIO:0000329", "label": "Pathogenic Supporting" }, "id": "0030", "label": "PM2", "type": "Criterion" }, "evidenceLine": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1636/1638", "evidenceItem": [ { "@id": "CG-PCER:curatorInference/CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "comments": "The highest MAF in gnomADv4.0 is 0.000002705 (3/1108866 alleles) in the European (non-Finnish) population. This is below the SCID VCEP specified threshold of <0.00002412 (PM2_supporting).", "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "id": "CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "type": "InfFromBkgrndSciKnow" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1636/1638", "type": "EvidenceLine" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/1/1637", "statementOutcome": { "@id": "SEPIO:0000224", "label": "Met" }, "type": "CriterionAssessment" } ], "evidenceStrength": { "@id": "https://obofoundry.org/sepio" }, "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1636", "type": "EvidenceLine" }, { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1825", "evidenceItem": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/ei/1/1826", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "criterion": { "@id": "https://obofoundry.org/sepio/clingen/0039", "defaultStrength": { "@id": "https://obofoundry.org/sepio/SEPIO:0000216", "id": "SEPIO:0000216", "label": "Pathogenic Moderate" }, "id": "0039", "label": "PS3", "type": "Criterion" }, "evidenceLine": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1825/1827", "evidenceItem": [ { "@id": "CG-PCER:curatorInference/CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "comments": "A luciferase reporter construct was cotransfected into heterologous cells together with an expression vector containing FOXN1. The Val294Ile variant had 18% luciferase activity compared to WT which is below the <50% threshold for PS3_moderate (PMID: 37419334).", "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "id": "CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "type": "InfFromBkgrndSciKnow" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1825/1827", "type": "EvidenceLine" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/1/1826", "statementOutcome": { "@id": "SEPIO:0000224", "label": "Met" }, "type": "CriterionAssessment" } ], "evidenceStrength": { "@id": "https://obofoundry.org/sepio" }, "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1825", "type": "EvidenceLine" }, { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1615", "evidenceItem": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/ei/1/1616", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "criterion": { "@id": "https://obofoundry.org/sepio/clingen/006", "defaultStrength": { "@id": "https://obofoundry.org/sepio/SEPIO:0000216", "id": "SEPIO:0000216", "label": "Pathogenic Moderate" }, "id": "006", "label": "PM1", "type": "Criterion" }, "evidenceLine": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1615/1617", "evidenceItem": [ { "@id": "CG-PCER:curatorInference/CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "comments": "The missense variant is located within the DNA binding forkhead domain (amino acids 270-367) at amino acid position 294, and thus meets PM1.", "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "id": "CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "type": "InfFromBkgrndSciKnow" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1615/1617", "type": "EvidenceLine" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/1/1616", "statementOutcome": { "@id": "SEPIO:0000224", "label": "Met" }, "type": "CriterionAssessment" } ], "evidenceStrength": { "@id": "https://obofoundry.org/sepio" }, "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1615", "type": "EvidenceLine" }, { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1609", "evidenceItem": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/ei/1/1610", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "criterion": { "@id": "https://obofoundry.org/sepio/clingen/0027", "defaultStrength": { "@id": "https://obofoundry.org/sepio/SEPIO:0000329", "id": "SEPIO:0000329", "label": "Pathogenic Supporting" }, "id": "0027", "label": "PM3", "type": "Criterion" }, "evidenceLine": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1609/1611", "evidenceItem": [ { "@id": "CG-PCER:curatorInference/CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "comments": "Patient P2 (PMID: 30903456) is homozygous for this variant (1pt; PM3_supporting).", "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "id": "CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "type": "InfFromBkgrndSciKnow" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1609/1611", "type": "EvidenceLine" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/1/1610", "statementOutcome": { "@id": "SEPIO:0000224", "label": "Met" }, "type": "CriterionAssessment" } ], "evidenceStrength": { "@id": "https://obofoundry.org/sepio" }, "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1609", "type": "EvidenceLine" }, { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1774", "evidenceItem": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/ei/1/1775", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "criterion": { "@id": "https://obofoundry.org/sepio/clingen/0048", "defaultStrength": { "@id": "https://obofoundry.org/sepio/SEPIO:0000329", "id": "SEPIO:0000329", "label": "Pathogenic Supporting" }, "id": "0048", "label": "PM5", "type": "Criterion" }, "evidenceLine": [ { "@id": "https://erepo.genome.network/evrepo/api/interpretation/CA398323709/MONDO:0011132/113/el/0/1774/1776", "evidenceItem": [ { "@id": "CG-PCER:curatorInference/CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "contribution": [ { "agent": { "@id": "https://erepo.genome.network/evrepo/api//agent/CG_50091_EP170474596929316", "id": "CG-PCER-AGENT:CG_50091_EP170474596929316", "type": "Agent" }, "comments": "This variant occurs at the same codon as Val294Leu which has been classified as Likely Pathogenic by the SCID VCEP (PM5_supporting).", "contributionDate": { "date": "2024/7/29", "description": "Date on which this evidence was provided" }, "contributionRole": { "@id": "https://obofoundry.org/sepio/0000156", "id": "SEPIO:0000516", "label": "curator role", "type": "ContributoryRole" }, "type": "Contribution" } ], "id": "CA398323709/MONDO:0011132/113/ci/CA398323709/MONDO:0011132/113.002", "type": "InfFromBkgrndSciKnow" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1774/1776", "type": "EvidenceLine" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/1/1775", "statementOutcome": { "@id": "SEPIO:0000224", "label": "Met" }, "type": "CriterionAssessment" } ], "evidenceStrength": { "@id": "https://obofoundry.org/sepio" }, "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113/0/1774", "type": "EvidenceLine" } ], "id": "CG-PCER-VARINT:CA398323709/MONDO:0011132/113", "metadata": { "created": "2024-09-28T05:14:14.978Z", "note": "DISCLAIMER: While the data/content in this document is approved by ClinGen expert panel(s), the SEPIO schema presented here is an initial prototype and has not been reviewed nor finalized by the ClinGen Data Exchange Modeling Team. We expect it to differ significantly from the final schema.", "producedAtUTC": "Sat, 28 Sep 2024 05:14:14 -0000", "schemaLabel": "Evidence Repository.Beta-1 (Unofficial)", "version": "1.0.0" }, "statementOutcome": { "@id": "https://loinc.org/LA6668-3", "id": "LN:LA6668-3", "label": "Pathogenic" }, "type": "VariantPathogenicityInterpretation", "uuid": "eab22ed7-b1c5-444f-ba9f-0de25bfa14bd", "variant": { "@id": "https://reg.genome.network/allele/CA398323709", "id": "CAR:CA398323709", "relatedContextualAllele": [ { "alleleName": [ { "name": "NM_003593.3:c.880G>A" } ], "preferred": true } ], "type": "CAR" } }, "metadata": { "rendered": { "by": "https://erepo.genome.network/evrepo/api/summary/srvc", "when": "2026-11-02T22:32:34.668Z" } }, "status": { "code": 200, "name": "OK" } }