The NM_000552.5:c.1451A>G variant in VWF is a missense variant predicted to cause substitution of histidine by arginine at amino acid 484. The Grpmax filtering allele frequency in gnomAD v4.1 is 0.7007 (based on 64214/91042 alleles in the south Asian population, including 22835 homozygotes), which is higher than the ClinGen VWD VCEP threshold of >0.1 for BA1. The computational predictor REVEL gives a score of 0.0630, which is below the ClinGen VWD VCEP threshold of <0.290 and does not predict a damaging effect on VWF function (BP4). Additionally, the computational splicing predictor SpliceAI indicated that the variant has no impact on splicing. This variant is also referenced as a polymorphic variant in several reports (PMIDs 38308883, 37017006). In summary, this variant meets the criteria to be classified as benign for hereditary von Willebrand disease based on the ACMG/AMP criteria applied, as specified by the ClinGen VWD VCEP: BA1, BP4