The NM_000552.5:c.3569G>T variant in VWF is a missense variant predicted to cause substitution of cysteine by phenylalanine at amino acid 1190. At least 1 patient with this variant displayed excessive mucocutaneous bleeding (evidenced by inclusion in a VWD diagnosed cohort) as well as laboratory phenotypes of very low VWF activity VWF:GP1b and VWF:Collagen binding assay, low activity/VWF:Ag ratio, and loss of high molecular weight multimers, which together are highly specific for VWD type 2A. (PP4_moderate, PMID 36299619). Another missense variant NM_000552.5:c.3568T>C (p.Cys1190Arg) in the same codon has been classified as likely pathogenic for VWD type 2A by the ClinGen VWD VCEP (PM5). The computational predictor REVEL gives a score of 0.955, which is above the ClinGen VWD VCEP threshold of >0.644 and predicts a damaging effect on VWF function (PP3). The computational predictor REVEL gives a score of 0.955, which is above the ClinGen VWD VCEP threshold of >0.644 and predicts a damaging effect on VWF function (PP3). In summary, this variant meets the criteria to be classified as likely pathogenic for autosomal dominant VWD type 2A based on the ACMG/AMP criteria applied, as specified by the ClinGen VWD VCEP: PS4_Supporting, PM5_Supporting, PP3, PM2_Supporting. (ClinGen von Willebrand Disease Expert Panel Specifications to the ACMG/AMP Variant Interpretation Guidelines for VWF Version 1.0.0; date of approval)