NM_001034853.2(RPGR):c.3407G>A (p.Gly1136Asp) variant is a missense variant encoding the substitution of glycine with aspartic acid at amino acid 1136. The computational predictor REVEL gives a score of 0.053, which is below the ClinGen X-linked IRD VCEP threshold of <0.183 and predicts a non-damaging effect on RPGR function. Additionally, the splicing impact predictor SpliceAI gives a delta score of 0.00, which is below the ClinGen X-linked IRD VCEP recommended threshold of <0.1 and does not strongly predict an impact on splicing (BP4_moderate). This variant is present in gnomAD v.4.1.0 at a frequency of 0.0008861 among hemizygous individuals, with 352 variant alleles / 397,264 total alleles, which is higher than the ClinGen X-linked IRD VCEP BA1 threshold of >0.00005 (BA1). This variant has been reported in at least 1 male proband and 2 females. The male proband had insufficient reported details and did not meet the PS4 requirement of some functional vision impairment in an affected male by age 30 years, or decreased/absent cone and/or rod electroretinogram responses (PMID: 32679846), so PS4_supporting was not met. In summary, this variant is classified as benign for RPGR-related retinopathy based on the ClinGen X-linked Inherited Retinal Disease Expert Panel Specifications to the ACMG/AMP Variant Interpretation Guidelines for RPGR Version 1.0.0; BA1 and BP4_moderate. (date of approval 05/16/2025).