The c.2932T>C variant in ATM is a missense variant predicted to cause substitution of serine by proline at amino acid 978 (p.Ser978Pro). This variant has been observed with the variant c.8395_8404del (p.F2799Kfs*4) which is classified as pathogenic by the HBOP VCEP (ClinVar SCV005627268.1) in one individual with Ataxia-Telangiectasia and 6 individuals with no features of Ataxia-Telangiectasia (PMID: 26896183, Ambry internal data) (PM3/BP2 points: +2). The phase of the variants was suspected to be in cis by family testing. This variant has also been observed with other pathogenic ATM variants in 21 individuals with no features of Ataxia-Telangiectasia (Ambry internal data) (PM3/BP2 points: -42) (BP2_Strong met, -40 points). The highest population minor allele frequency in gnomAD v4.1.0 is 0.004874 in the South Asian population, which is higher than the ClinGen HBOP VCEP threshold (>0.0005) for BS1, and therefore meets this criterion. The computational predictor REVEL gives a score of 0.87, which is above the threshold of 0.733, evidence that correlates with impact to ATM function (PP3). Although there are both pathogenic and benign types of evidence for this variant, the pathogenic evidence is not considered inconsistent with the final classification. In summary, this variant meets the criteria to be classified as benign for autosomal dominant ATM-related cancer predisposition and autosomal recessive Ataxia-Telangiectasia based on the ACMG/AMP criteria applied as specified by the HBOP VCEP. (BS1, BP2_strong, PP3)