The c.844del variant in MYOC is a deletion of a single nucleotide, predicted to encode a frameshift with consequent premature termination of the protein at codon 64 of the frameshift, or amino acid 345 (p.Gln282ArgfsTer64). This variant is predicted to involve ≥ 10% of the protein within the conserved olfactomedin domain, meeting PM4. The highest minor allele frequency of this variant was in the African/African American population of gnomAD (v2.1.1) = 0.00006155 (1 allele out of 16,246), which met the ≤ 0.0001 threshold set for PM2_Supporting in a population of at least 10,000 alleles. There was no computational or functional evidence predicting a damaging or benign impact of this variant on MYOC function. Only 1 proband with primary open angle glaucoma had been reported (E Souzeau pers. comm.), not meeting the ≥ 2 probands threshold required to meet PS4_Supporting. In summary, this variant met the criteria to receive a score of 3 and to be classified as a variant of uncertain significance (uncertain significance classification range -1 to 5) for primary open angle glaucoma based on the ACMG/AMP criteria met, as specified by the ClinGen Glaucoma VCEP (v1, 12 Oct 2021): PM4, PM2_Supporting.