The BMPR2 c.1882A>G variant is a missense variant predicted to result in an arginine to serine substitution at amino acid position 842 (p.Arg842Ser). The highest population minor allele frequency in gnomAD v.2.1.1 controls is 0.000070 in the European (non-Finnish) population thus meeting the threshold for PM2_supporting, resultantly neither BS1 nor BA1 were met. Computational evidence for pathogenicity as evaluated by REVEL generated a score of 0.468 indicating that neither BP4 nor PP3 were met. Additionally, the SpliceAI algorithm predicts no deleterious impact on putative acceptor or donor splice sites. The BMPR2 C-terminus is of unclear functional and/or structural relevance, hence PM1 is not met. Due to no evidence of familial segregation PP1, PM6 and PS2 were not assessed. BS3 and PS3 were not evaluated as functional data is unavailable for this variant. In summary, the variant meets the criteria to be classified as a variant of uncertain significance (VUS) for pulmonary arterial hypertension based on the ACMG/AMP criteria applied, as specified by the ClinGen Pulmonary Hypertension VCEP: PM2_supporting (VCEP specification version 1.1, 1/18/2024).