After a comprehensive literature search of the synonymous variant NM_000212.3(ITGB3):c.261C>G (p.Ala87=), no individuals with Glanzmann thrombasthenia were reported with the variant and has only been observed in a ostensibly healthy population. The variant has a minor allele frequency of 0.00006 (1/16256 alleles) in the African/African American population in gnomAD, which meets the threshold criteria for PM2_supporting. In silico predictor spliceAI revealed that the synonymous mutation is not expected to impact splicing and a PhyloP score of 1.32 shows that the nucleotide position is not highly conserved (BP4, BP7). Due to conflicting evidence, this variant is classified as likely benign for autosomal recessive Glanzmann Thrombasthenia based on the ACMG/AMP criteria applied, as specified by the ClinGen PD-VCEP: PM2_Supporting, BP4, BP7. (PD VCEP specifications version 2.1).