The NM_000419.5:c.2929_2930del (p.Glu979SerfsTer56) variant in ITGA2B is a frameshift variant that may cause a premature stop codon that is predicted to escape nonsense mediated decay, however it leads to alteration of a functionally important region (alters amino acids 979-1034, which includes the transmembrane domain) in a gene where loss-of-function is an established disease mechanism (PVS1_Strong). At least one patient (Proband GT 26 in PMID: 16463284) with this variant displayed mucocutaneous bleeding and impaired aggregation with all agonists except ristocetin, which is highly specific for Glanzmann thrombasthenia (PP4_moderate). This variant is absent from gnomAD v2.1.1 (PM2_Supporting). In summary, this variant meets the criteria to be classified as likely pathogenic for autosomal recessive Glanzmann Thrombasthenia based on the ACMG/AMP criteria applied, as specified by the ClinGen PD VCEP: PVS1_strong, PP4_moderate, and PM2_supporting. (VCEP specifications version 2; date of approval 12/21/2021).